Hotels in Santee SC
Find your home away from home in Santee Cooper County, South Carolina whether you want to be steps from the lake or conveniently near I-95—pretty much the same in our case! We have a number of excellent hotels from tried-and-true favorites like Holiday Inn and Best Western Plus to local favorites like Historic Clark’s Inn, dating back to 1946. No matter what suits you and your party best, you’ll find it here. Book your stay today!